The author presents the previously unknown text of the outstanding Soviet philosopher and historian of science Boris Mikhailovich Hessen. The author analyzes the report of Boris M. Hessen at the Second international Congress on the history of science and technology in London (1931). He considers as well some published works of B.M. Hessen, mainly his book on the philosophical interpretation of the theory of relativity. He argues that it is time to start introducing unpublished texts by B.M. Hessen (...) into scientific circulation. This will make the study of his work more thorough and increase the reliability of conclusions made by specialists in Hessen’s legacy. This publication offers the reader the text of B.M. Hessen, extracted from the archive: the report of B.M. Hessen at a meeting of the Presidium of the Communist Academy about the trip to the London Congress. (shrink)

Ernst Mayr argued that the emergence of biology as a special science in the early nineteenth century was possible due to the demise of the mathematical model of science and its insistence on demonstrative knowledge. More recently, John Zammito has claimed that the rise of biology as a special science was due to a distinctive experimental, anti-metaphysical, anti-mathematical, and anti-rationalist strand of thought coming from outside of Germany. In this paper we argue that this narrative neglects the important role played (...) by the mathematical and axiomatic model of science in the emergence of biology as a special science. We show that several major actors involved in the emergence of biology as a science in Germany were working with an axiomatic conception of science that goes back at least to Aristotle and was popular in mid-eighteenth-century German academic circles due to its endorsement by Christian Wolff. More specifically, we show that at least two major contributors to the emergence of biology in Germany—Caspar Friedrich Wolff and Gottfried Reinhold Treviranus—sought to provide a conception of the new science of life that satisfies the criteria of a traditional axiomatic ideal of science. Both C.F. Wolff and Treviranus took over strong commitments to the axiomatic model of science from major philosophers of their time, Christian Wolff and Friedrich Wilhelm Joseph Schelling, respectively. The ideal of biology as an axiomatic science with specific biological fundamental concepts and principles thus played a role in the emergence of biology as a special science. (shrink)

This volume brings together the religious and philosophical writings of the founders of Russian religious philosophy, Aleksei Khomiakov and Ivan Kireevsky. Both began their intellectual careers in the literary world of the 1820s. The texts collected here make the philosophical concepts of Sobornost (community, universality, wholeness, ecumenicity) and integral knowledge, available to western readers. Based on the primacy of the heart, the spiritual wholeness of the human being and the cognitive will, integral knowing moves beyond rationality to union with the (...) object of knowledge in knowing. This book provides an introduction to Russian religious philosophy, and a profound, meditative text for anyone concerned with human and spiritual unity. Also included are two responses to Slavophile ideas by the prominent Russian philosophers Pavel Florensky and Nikolai Berdiaev. (shrink)

The volume collects classics of Marxist historiography of science, including a new translation of Boris Hessen's “The Social and Economic Roots of Newton's ...

In this paper, we analyse conceptions of induction and certainty in Wolff and Crusius, highlighting their competing conceptions of physics. We discuss (i) the perspective of Wolff, who assigned induction an important role in physics, but argued that physics should be an axiomatic science containing certain statements, and (ii) the perspective of Crusius, who adopted parts of the ideal of axiomatic physics but criticized the scope of Wolff’s ideal of certain science. Against interpretations that take Wolff’s proofs in physics to (...) be based on empirical statements that are probable, we show how inductively established statements, coupled with assumptions concerning the uniformity of nature, can be certain according to Wolff. We examine Crusius’ little known work on physics and show that he attacked Wolff, arguing that many statements of physics are probable. We provide a discussion of the reception of methodological rules similar to Newton’s Regulae Philosophandi, discussing different interpretations of such rules. We conclude by briefly hinting at how the debate between Wolff and Crusius provides historical context for understanding Kant’s philosophy of natural science. (shrink)

Boris Kment takes a new approach to the study of modality that emphasises the origin of modal notions in everyday thought. He argues that the concepts of necessity and possibility originate in counterfactual reasoning, which allows us to investigate explanatory connections. Contrary to accepted views, explanation is more fundamental than modality.

Sleep spindles are frequently studied for their relationship with state and trait cognitive variables, and they are thought to play an important role in sleep-related memory consolidation. Due to their frequent occurrence in NREM sleep, the detection of sleep spindles is only feasible using automatic algorithms, of which a large number is available. We compared subject averages of the spindle parameters computed by a fixed frequency (11-13 Hz for slow spindles, 13-15 Hz for fast spindles) automatic detection algorithm and the (...) individual adjustment method (IAM), which uses individual frequency bands for sleep spindle detection. Fast spindle duration and amplitude are strongly correlated in the two algorithms, but there is little overlap in fast spindle density and slow spindle parameters in general. The agreement between fixed and manually determined sleep spindle frequencies is limited, especially in case of slow spindles. This is the most likely reason for the poor agreement between the two detection methods in case of slow spindle parameters. Our results suggest that while various algorithms may reliably detect fast spindles, a more sophisticated algorithm primed to individual spindle frequencies is necessary for the detection of slow spindles as well as individual variations in the number of spindles in general. (shrink)

This volume sets out to address the question as to whether and how the critical conception of objectivity could still be relevant in contemporary philosophy. This means reflecting on the validity of the ascription of certaindefects to the Kantian system, as well as on their very description as defects. In order to do so, the volume brings together presentations that treat Kantian objectivity from many different angles. Some are more traditionally exegetical in nature, and discuss the interpretation of concepts within (...) or traits of Kant’s philosophy. Others trace the fate of the Kantian legacy in later philosophical and scientific thought. Still others reflect on the potential of transcendental perspectives for con-temporary philosophy and science. It is this variety in focus that makes the engagement with critical objectivity in this volume of interest not only to professional historians of philosophy and science, but to researchers engaged with the philosophical aspects of objectivity in their fields in general. (shrink)

Social networks play a significant role in learning and thus in farmers’ adoption of new agricultural technologies. This study examined the effects of social network factors on information acquisition and adoption of new seed varieties among groundnut farmers in Uganda and Kenya. The data were generated through face-to-face interviews from a random sample of 461 farmers, 232 in Uganda and 229 in Kenya. To assess these effects two alternative econometric models were used: a seemingly unrelated bivariate probit model and a (...) recursive bivariate probit model. The statistical evaluation of the SUBP shows that information acquisition and adoption decisions are interrelated while tests for the RBP do not support this latter model. Therefore, the analysis is based on the results obtained from the SUBP. These results reveal that social network factors, particularly weak ties with external support, partially influence information acquisition, but do not influence adoption. In Uganda, external support, gender, farm size, and geographic location have an impact on information acquisition. In Kenya, external support and geographic location also have an impact on information acquisition. With regard to adoption, gender, household size, and geographic location play the most important roles for Ugandan farmers, while in Kenya information from external sources, education, and farm size affect adoption choice. The study provides insight on the importance of external weak ties in groundnut farming, and a need to understand regional differences along gender lines while developing agricultural strategies. This study further illustrates the importance of farmer participation in applied technology research and the impact of social interactions among farmers and external agents. (shrink)

One of the great problems of caregivers and health professionals in recent times has been the so-called compassion fatigue and its association with burnout syndrome. Another pole of compassion has been described in terms of compassion satisfaction. Both propositions could be problematic in the caregiving setting. This is an analytical reflective article that through an apparent aporia tries to problematize and propose a theoretical synthesis that allows to denote compassion as a virtue in Aristotelian terms. To this end, it resorts (...) to etymologies, translations and mainly to the classical theoretical references regarding compassion fatigue, compassion satisfaction and, of course, Aristotelian ethics. This is a theoretical bet that leaves open the discussion regarding the dichotomies compassion fatigue and compassion satisfaction; apathy and hyperpathy; and proposes to rethink compassion as a virtue, a reasoned middle ground, contextualized in the framework of care between two possible excesses. (shrink)

In this article we present a notion of “logical perfection”. We first describe through examples a notion of logical perfection extracted from the contemporary logical concept of categoricity. Categoricity (in power) has become in the past half century a main driver of ideas in model theory, both mathematically (stability theory may be regarded as a way of approximating categoricity) and philosophically. In the past two decades, categoricity notions have started to overlap with more classical notions of robustness and smoothness. These (...) have been crucial in various parts of mathematics since the nineteenth century. We postulate and present the category of logical perfection. We draw on various notions of perfection from mathematics of the 19th and 20th centuries and then trace the relation to the concept of categoricity in power as a logical notion of what a “mathematically perfect” structure is. (shrink)

We describe approximation algorithms for MAX SAT with performance ratios arbitrarily close to 1, in particular, when performance ratios exceed the limits of polynomial-time approximation. Namely, given a polynomial-time α-approximation algorithm , we construct an -approximation algorithm . The algorithm runs in time of the order ck, where k is the number of clauses in the input formula and c is a constant depending on α. Thus we estimate the cost of improving a performance ratio. Similar constructions for MAX 2SAT (...) and MAX 3SAT are also described. Taking known algorithms as , we obtain particular upper bounds on the running time of. (shrink)

We realize the Jiang-Su algebra, all UHF algebras, and the hyperfinite II1factor as Fraïssé limits of suitable classes of structures. Moreover by means of Fraïssé theory we provide new examples of AF algebras with strong homogeneity properties. As a consequence of our analysis we deduce Ramsey-theoretic results about the class of full-matrix algebras.

Commonly, a switch between networks mediating memory encoding and those mediating retrieval is observed. This may not only be due to differential involvement of neural resources due to distinct cognitive processes but could also reflect the formation of new memory traces and their dynamic change during consolidation. We used resting state fMRI to measure functional connectivity (FC) changes during post-encoding rest, hypothesizing that during this phase, new functional connections between encoding- and retrieval-related regions are created. Interfering and reminding tasks served (...) as experimental modulators to corroborate that the observed FC differences indeed reflect changes specific to post-encoding rest. The right inferior occipital and fusiform gyri (active during encoding) showed increased FC with the left inferior frontal gyrus and the left middle temporal gyrus (MTG) during post-encoding rest. Importantly, the left MTG subsequently also mediated successful retrieval. This finding might reflect the formation of functional connections between encoding- and retrieval-related regions during undisturbed post-encoding rest. These connections were vulnerable to experimental modulation: Cognitive interference disrupted FC changes during post-encoding rest resulting in poorer memory performance. The presentation of reminders also inhibited FC increases but without affecting memory performance. Our results contribute to a better understanding of the mechanisms by which post-encoding rest bridges the gap between encoding- and retrieval-related networks. (shrink)

Using the Friedman-Koepke Hyperfine Structure Theory of [2], we provide a short construction of a gap 1 morass in the constructible universe.

Mindfulness-based interventions have proved effective in reducing various clinical symptoms and in improving general mental health and well-being. The investigation of the mechanisms of therapeutic change needs methods for assessment of mindfulness. Existing self-report measures have, however, been strongly criticized on various grounds, including distortion of the original concept, response bias, and other. We propose a psychophysiological method for the assessment of the mindfulness learned through time-limited mindfulness-based therapy by people who undergo meditation training for the first time. We use (...) the individual pre-post-therapy changes (dERPi) in the event-related brain potentials (ERPs) recorded in a passive meditation task as a measure of increased mindfulness. dERPi is computed through multivariate assessment of individual participant's ERPs. We tested the proposed method in a group of about 70 recurrently depressed participants, randomly assigned in 1.7:1 ratio to mindfulness-based cognitive therapy (MBCT) or cognitive therapy (CT). The therapy outcome was measured by the long-term change (dDS) relative to baseline in the depression symptoms (DS) assessed weekly, for 60 weeks, by an online self-report questionnaire. We found a strong, highly significant, negative correlation (r = -0.55) between dERPi (mean = 0.4) and dDS (mean = -0.7) in the MBCT group. Compared to this result, the relationship between dDS and the other (self-report) measures of mindfulness we used was substantially weaker and not significant. So was also the relationship between dERPi and dDS in the CT group. The interpretation of dERPi as a measure of increased mindfulness was further supported by positive correlations between dERPi and the other measures of mindfulness. In this study, we also replicated a previous result, namely, the increase (dLCNV) of the late contingent negative variation (LCNV) of the ERP in the MBCT group, but not in the control group (in this case, CT). We interpreted dLCNV as a measure of increased meditative concentration. The relationship between dLCNV and dDS was, however, very week, which suggests that concentration might be relatively unimportant for the therapeutic effect of mindfulness. The proposed psychophysiological method could become an important component of a "mindfulness test battery" together with self-report questionnaires and other newly developed instruments. (shrink)

Regular musical activity as a complex multimodal lifestyle activity is proposed to be protective against age-related cognitive decline and Alzheimer’s disease. This cross-sectional study investigated the association and interplay between musical instrument playing during life, multi-domain cognitive abilities and brain morphology in older adults from the DZNE-Longitudinal Cognitive Impairment and Dementia Study study. Participants reporting having played a musical instrument across three life periods were compared to controls without a history of musical instrument playing, well-matched for reserve proxies of education, (...) intelligence, socioeconomic status and physical activity. Participants with musical activity outperformed controls in global cognition, working memory, executive functions, language, and visuospatial abilities, with no effects seen for learning and memory. The musically active group had greater gray matter volume in the somatosensory area, but did not differ from controls in higher-order frontal, temporal, or hippocampal volumes. However, the association between gray matter volume in distributed frontal-to-temporal regions and cognitive abilities was enhanced in participants with musical activity compared to controls. We show that playing a musical instrument during life relates to better late-life cognitive abilities and greater brain capacities in OA. Musical activity may serve as a multimodal enrichment strategy that could help preserve cognitive and brain health in late life. Longitudinal and interventional studies are needed to support this notion. (shrink)

Cocaine use disorder is associated with maladaptive decision-making behavior, which strongly contributes to the harmful consequences of chronic drug use. Prior research has shown that cocaine users exhibit impaired neuropsychological test performances, particularly with regard to attention, learning, and memory but also in executive functions such as decision-making and impulse control. However, to what extent cocaine users show impaired decision-making under risk without feedback has not yet been investigated systematically. Therefore, to examine risk-taking behavior, 31 chronic cocaine users and 26 (...) stimulant-naïve healthy controls who were part of the Zurich Cocaine Cognition Study, performed the Randomized Lottery Task (RALT) with winning lotteries consisting of an uncertain and a certain prospect. Results revealed that risky decisions were associated with male sex, increased cocaine use in the past year, higher cocaine concentrations in the hair, and younger age. In addition, higher levels of cocaine in the hair and cumulative lifetime consumption were associated with risky decisions, whereas potentially confounding factors including cognition and psychiatric symptoms had no significant effect. Taken together, our results indicate that cocaine users who increased their consumption over a period of 1 year show deficits in the processing of risky information accompanied with increased risk-taking. Future research should analyse whether risky decisions could potentially serve as a prognostic marker for cocaine use disorder. (shrink)

On the received view, counterfactuals are analysed using the concept of closeness between possible worlds: the counterfactual 'If it had been the case that p, then it would have been the case that q' is true at a world w just in case q is true at all the possible p-worlds closest to w. The degree of closeness between two worlds is usually thought to be determined by weighting different respects of similarity between them. The question I consider in the (...) paper is which weights attach to different respects of similarity. I start by considering Lewis's answer to the question and argue against it by presenting several counterexamples. I use the same examples to motivate a general principle about closeness: if a fact obtains in both of two worlds, then this similarity is relevant to the closeness between them if and only if the fact has the same explanation in the two worlds. I use this principle and some ideas of Lewis's to formulate a general account of counterfactuals, and I argue that this account can explain the asymmetry of counterfactual dependence. The paper concludes with a discussion of some examples that cannot be accommodated by the present version of the account and therefore necessitate further work on the details. (shrink)

We argue that the most‐promising area of clinical application of microarrays in the foreseeable future is the diagnostics and monitoring of infectious diseases. Microarrays for the detection and characterization of human pathogens have already found their way into clinical practice in some countries. After discussing the persistent, yet often underestimated, importance of infectious diseases for public health, we consider the technologies that are best suited for the detection and clinical investigation of pathogens. Clinical application of microarray technologies for the detection (...) of mycobacteria, Bacillus anthracis, HIV, hepatitis and influenza viruses, and other major pathogens, as well as the analysis of their drug‐resistance patterns, illustrate our main thesis. BioEssays 30:673–682, 2008. © 2008 Wiley Periodicals, Inc. (shrink)

Starting from the idea that functions are formally similar to actions in that they are described and explained in a similar way, so that both admit of an accordion effect, I turn to Anscombe’s insight that the point of practical reasoning is to render explicit the relation between the different descriptions of an action generated by the accordion effect. The upshot is, roughly, that an item has a function if what it does can be accounted for by functional reasoning. Put (...) differently, a part of a system has a function if what it does is a functional part of what the system does. (shrink)

In this paper, I make a contribution to a naturalistically-minded theory of truthmakers by proposing a solution to the nasty problem of truthmakers for negative truths. After formulating the difficulty, I consider and reject a number of solutions to the problem, including Armstrong's states of affairs of totality, incompatibility accounts, and JC Beall 's polarity view. I then defend the position that absences of truthmakers are real and are responsible for making negative truths true. According to the positive account of (...) absences I offer, absences of contingent states of affairs are causally relevant mind-independent features of the physical world, located within space and time, and capable of being discovered by scientific inquiry. Recognition of the reality of absences strengthens truthmaker theory as a naturalistic metaphysics, as truth and falsity of each and every contingent proposition finds an ontological grounding in some region of the physical universe. (shrink)